Oxidised form of vitamin K1

Cosmetic products containing an oxidised form of vitamin K1 (phytonadione epoxide)

The use of vitamin K1 (phytonadione) has been banned in cosmetic products at European level for more than 10 years, following cases of allergic contact dermatitis.

Vitamin K1 is an important therapeutic agent in the treatment of various coagulation disorders. In the event of allergic sensitisation acquired through topical application of vitamin K1 contained in cosmetic products, a person may develop an allergic reaction to vitamin K1 treatment and/or may not be able to receive vitamin K1 treatment if necessary in the future.

Oxidised form of vitamin K1 (phytonadione epoxide)

An oxidised form of vitamin K1 (phytonadione epoxide) is currently used in cosmetic products for its astringent properties: body lotions to reduce the appearance of haematomas or skin redness after aesthetic laser treatments or mesotherapy sessions; face creams to reduce the appearance of dark circles around the eyes; etc.

New cases of allergic contact dermatitis also appear to be caused by the oxidised form of vitamin K1 (phytonadione epoxide) contained in cosmetic products, which could result in cross-sensitisation to vitamin K1.

You can check whether or not a cosmetic product contains phytonadione epoxide by reading the list of ingredients mentioned on the labelling.

What to do if you suspect the occurrence of an undesirable effect

• Stop using the cosmetic product in question immediately and consult a doctor if necessary.
  
  
• Report the undesirable effect or serious undesirable effect to the responsible person named on the label and/or to us using the undesirable effect report form (Word, 79 Kb), specifying the requested information.